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We validated the impact of CENPT-GCLC on GSH synthesis, resulting in a decrease in lipid peroxidation and ROS levels, mediating RCC ferroptosis resistance and proliferation

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

We showed that MAPL, a SUMO E3 ligase present in mitochondria, can promote the SUMO1 modification of Drp1, facilitate its mitochondrial translocation and induce detrimental fission, leading to mitochondrial dysfunction, NPC apoptosis, and IVDD

Expert pain specialists understand this and recommend T3 supplementation to patients with significant pain or on narcotic pain medications

While it is important to note that concerns exist regarding mtDNA-HG association studies, currently, there is concordance on the association between DAMD susceptibility and resistance, lending credence to the idea that mtDNA influences DAMD progression and pathology

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