In contrast, the United States regulates probiotics under multiple pathways (foods, dietary supplements, drugs, biologics), using Generally Recognized As Safe (GRAS) notices for food uses and more demanding drug/biologic pathways for LBPs intended to treat or prevent disease (521)
These reductions are believed to alleviate neuroinflammation and neurogenic pain, crucial elements in migraine pathophysiology
Zhang M, Xuan S, Bouxsein ML, Von Stechow D, Akeno N, Faugere MC, et al
doi: 10.3382/ps/pez497, 5
Seinerzeit hatten 54 Erwachsene (Nichtraucher) ein halbes Jahr lang tglich 250 mg oder 1000 mg Glutathion eingenommen, wobei sich ein Anstieg des Spiegels schon nach einem Monat, aber noch deutlicher nach 3 und 6 Monaten beobachten liess
Secondary Outcomes: Visual Analog Scale (VAS) for global pain Fibromyalgia Impact Questionnaire (FIQ) for physical function Beck Depression Inventory (BDI) for mood Health Status Questionnaire 2.0 for quality of life Assessments were made at: Baseline (week 0) Week 8 (end of treatment) Week 12 (4 weeks post-treatment) Results While both groups showed clinically significant improvements, particularly in pain and mood, no statistically significant differences between the treatment and placebo groups were found in primary or secondary outcomes
