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10.1210/endo-129-5-2799 215 TodaK.TakedaK.OkadaT.AkiraS.SaibaraT.KanameT.et al (2001)

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Prophylactic effect of riboflavin on pediatric migraine: a randomized, double-blind, placebo-controlled trial

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Research demonstrates that BPC-157 upregulates vascular endothelial growth factor receptor-2 (VEGFR2) at both mRNA and protein levels in endothelial cells without increasing VEGF-A itself, instead sensitizing cells to existing VEGF signaling while simultaneously activating the Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway