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247 Hyperglycemia is the motivation of excessive ROS and oxidative stress, while activating the inflammasome and exacerbating inflammation

As a result, the main melanogenesis regulator MITF is elevated after UVR, followed by an increase in other melanosomal proteins such as TYR, TRP-1 and TRP-2, leading to the stimulation of melanogenesis [47]

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Additional testing may be considered for people with a family history of premature heart disease, metabolic risk, abnormal cholesterol results, known cardiovascular disease, or uncertainty after standard testing: ApoB, Lp(a), and hs-CRP may help reveal particle burden, inherited risk, and inflammation that are not fully captured by LDL cholesterol alone