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A randomized trial of nortriptyline for severe chronic tinnitus

[DOI] [PubMed] [Google Scholar] 19.Arnadottir M, Brattstrom L, Simonsen O, et al

421,458 Alterations in the balance of descending modulatory pathways are hypothesized to sustain chronic pain states, with a reduction in inhibitory control and an increase in facilitatory activity within both the brain and spinal cord

This is a network of nerves located outside your central nervous system (brain and spinal cord)

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available via research suppliers and some compounding pharmacies