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Chemotherapy also targets various mitochondrial enzymes or proteins, including mitochondrial ribosome and ribosomal proteins (MRP), DNA polymerase subunit gamma (PolG), ATP synthase, and the calcium or other ion channels as the voltage-dependent anion channel 1 (VDAC1), the mitochondrial calcium uniporter (MCU) complex, and the mitochondrial permeability transition pore complex (mPTPC) [58]

Their elevated presence in cerebrospinal fluid and peripheral blood following neuroaxonal injury offers important diagnostic and prognostic utility (Sharma et al., 2024)

Following skin penetration, cercariae transform into schistosomula, enter the circulation and migrate via the blood and lymphatic vessels to the liver