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While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

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Effects of vitamin B12 on performance and circadian rhythm in healthy subjects

2012 Jul 29;736:78-84

Immediate, Noticeable Results Feel increased energy, mental clarity, and overall wellness within hours

I have insomnia for about 6 days after methylcobalamin injection (1000mg)