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When Nile Red is in the hydrophobic core of the nanoparticles, it is highly fluorescent and can be easily detected

In clinical trials, the most common adverse reactions (incidence 20%) of pemetrexed, when administered as a single-agent, are fatigue, nausea and anorexia

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As two negative regulators of p53, MDM2 and MDMX facilitate ferroptosis with or without p53, most likely by altering the lipid profile of cells (Venkatesh et al., 2020), which is confirmed by evidence that with the treatment of MDM2 inhibitor nutlin-3, p53 expression increases and leads to the suppression of X c system inhibitor-induced ferroptosis in HT-1080 cells (Tarangelo et al., 2018)