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Previous population studies have shown that AGEs significantly increased the expression of DPP-4 and promoted the release of soluble DPP-4 in renal tubular cells (173)

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Side Effects: Occasional irritation under the tongue (we prescribe it into a sublingual drop if the patient experiences this) Contraindications: Recent cancer due to increase in growth factors Dosage and Route: Optimizer is compounded into sublingual tablets, which dissolve under the tongue

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