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Further research is necessary to elucidate the roles of micronutrients in GD and their underlying mechanisms

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doi:10.1136/gut.16.3.193

Effects of HT and exogenous GSH on antioxidant enzymes activities, MDA content, O 2 production rate, and GSH redox homeostasis The activities of CAT, APX, G-POD, SOD and GR were stimulated by 13.0%, 25.2%, 35.4%, 16.6% and 14.4%, respectively, under the HT treatment, and by 20.3%, 40.1%, 54.2%, 7.8% and 28.2%, respectively, under the HT+GSH treatment compared to the NT treatment (Fig

Second, we provide a systematic and updated overview of glial contributions, highlighting emerging evidence that microglia act as primary drivers of iron-mediated neurotoxicity, and that astrocytes undergo dynamic phenotypic shifts regulated by pathways such as mTOR and CSE/YAP/FOXD3 mechanisms that modulate neuronal vulnerability in previously underappreciated ways