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In the rat, they represent only approximately 10% of the total number of OR, while in most other species (guinea pig, monkey, and human) they represent at least a third of the opioid binding population (Dhawan et al., 2012

Garca-Gimnez JL, Gimeno A, Gonzalez-Cabo P, Das F, Bolinches-Amors A, Moll B, et al

Despite a limited amount of data, it is reasonable to postulate that dysregulated control of macrophage survival in an inflamed environment could exaggerate inflammation, and this could be relevant to the initiation or progression of CD

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Dwita L.P., Yati K., Gantini S.N

These collectively trigger ferroptosis in periodontal ligament cells and gingival epithelial cells

doi: 10.3390/ijms222212298