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Activation of IGF signaling pathways promotes the growth, metastasis, and drug resistance in many types of human tumors, including mesenchymal, epithelial, and hematopoietic cancer [11,12,13]

In peritumoral hepatic tissues, the core clock genes exhibited phase advances relative to those in healthy controls, while renal tissues displayed phase delays, suggesting that tumor-derived signals disrupt clocks in distal organs (139)

Abstract Pediatric low-grade gliomas represent the most common childhood brain tumor class

YJ and HG made a lot of contributions in the revision of the manuscript

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