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ASPAT and ALAT activities in plasma were significantly reduced and histological examination of the liver, revealed a decrease in cellular edema and apoptotic cell count, as well as no hyperemia of the hepatic parenchyma

However, it is unclear if this abundance of thiomethyl derivates is related to a specific susceptibility of this individual to generate NAPQI metabolites, to the pregnancy itself (as sex steroids could be involved in the regulation of CYP2E1 ( 25 )) or to an accumulation of these metabolites in urine over time due to repeated intakes

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10.1016/j.wasman.2023.06.030 [DOI] [PubMed] [Google Scholar] Vora L

For example, a pioneering study on A