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Inflammatory factors stimulate increased brain microvascular permeability, such as IL-1, TNF-, and IL-6

Nie JY, Zhao Q

Its pathophysiology involves multiple interconnected mechanisms, including monoaminergic neurotransmitter depletion, impaired neurotrophic signaling, neuroinflammation accompanied by hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and glutamate-induced excitotoxicity (Medeir et al., 2020)

Figure 1 Statements Author contributions SL: Writing original draft

Significance between groups was detected using one-way analysis of variance (ANOVA) and then Tukeys multiple comparison test

However, it is banned by the World Anti-Doping Agency (WADA) for competitive athletes