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A significant proportion of these alcoholrelated harms are sustained by persons living with an alcohol use disorder (AUD)

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Furthermore, the simultaneous administration of 25% ethanol (at a single dose of 2.9 g/kg) and a 12.5% body area burn in mice resulted in a decrease in the expression of TJs and mucins, specifically affecting the genes claudin-4, claudin-8 in both ileal and colonic epithelial cells, as well as claudin-2 and mucin-3 in the intestinal tract [279]

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doi: 10.3390/jcm10153441

The cost reflects its premium formulation and the benefits it provides