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Nor-epinephrine, a major catecholamine that promotes adipocyte lipolysis (83, 84), is released in response to cold stimulation from terminal neurons that innervate fat cells (83) to mediate non-shivering thermogenesis (85-87) through the activation of -adrenergic receptors (-ARs)

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CD38-specific sdAbs, such as sdAb 2F8, characterized by our laboratory, showing excellent tumor targeting and their engineered constructs, such as biparatopic antibodies and chimeric antibodies, represent a new generation of theranostic agents for diagnosis and treatment CD38-expressing malignancies