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Figure 4 3.2.3 Ferroptosis-mediated renal interstitial fibrosis Renal interstitial fibrosisan endpoint of CKDis promoted by ferroptosis in AKI models ( Regarding the integrated pathogenic network linking ferroptosis with inflammation, hypoxia, and fibrosis, in this network, the initial AKI-induced tubular injury (e.g., from I/R or nephrotoxicity) directly triggers ferroptosis via mitochondrial dysfunction and iron overload

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Rusciani L, Proietti I, Paradisi A, Rusciani A, Guerriero G, Mammone A,