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First, the identified candidate genes and pathways were derived from transcriptomic and integrative bioinformatics analyses, and causal relationships with chemoresistance were not experimentally validated

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10.1073/pnas.2637002100 Proc

However, the activity of HIF signaling in diabetic kidney is still controversy with one study reported tubule-specific knockout of HIF-1 aggravated kidney dysfunction and renal histopathological alterations in streptozotocin-induced diabetic mice (Jiang et al., 2020), and another elegant study, on the contrary, found that a specific inhibitor of HIF-1 attenuates the manifestations of diabetic nephropathy in OVE26 type 1 diabetic mice (Nayak et al., 2016)

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