Am J Physiol-Endocrinol Metab (2014) 306(1):E6574
Use of a mixture consisting of or comprising a) (+)-(2E)-3-(1 ,3-Benzodioxol-5-yl)-N-phenyl-N-(tetrahydro-3-furanyl)-2-propenamide and b) (-)-(2E)-3-(1 ,3-Benzodioxol-5-yl)-N-phenyl-N-(tetrahydro-3-furanyl)-2-propenamide, wherein the ratio of the total amount of compound b) and the total amount of compound a) in the mixture is greater than 50 : 50, preferably greater than 75 : 25, preferably greater than 90 : 10, more preferably greater than 95 : 5, more preferably greater than 98 : 2, or of a mixture comprising compound b), wherein the mixture is free of compound a), or of (-)-(2E)-3-(1 ,3-Benzodioxol-5-yl)-N-phenyl-N-(tetrahydro-3-furanyl)-2-propenamide (compound b)) as cooling agent, preferably for in vitro and/or in vivo modulation of the cold and menthol receptor TRPM8, preferably as TRPM8 receptor agonist, and/or for induction of a cold sensation in a human and/or animal, and/or to achieve a cooling effect on the skin or mucosa
Jimenez PR, Martin-Cortazar C, Kourani O, Chiodo Y, Cordoba R, Dominguez-Franjo MP, et al
Patients exhibited decreased methylation and increased expression of GSTA4 compared to that in controls
May boost immune system function and enhance disease resistance Dosage, Concentration, Route of Administration Dosage: Seek advice from a licensed physician, medical director, or other healthcare provider when determining alpha lipoic acid injection doses
The peptide has a molecular weight of 711.868 g/mol (molecular formula CHNO
