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2.5 Altered autophagy mechanism (and role of GBA1 gene) Autophagy is a process that in normal conditions maintains cellular balance by recycling proteins and organelles, and acts as an adaptive mechanism that helps cells survive under stressful conditions

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Conclusion: DKK3 is expressed by activated fibroblasts within tumors and DKK3+ fibroblasts have a tumor promoting activity in both primary liver cancer types, HCC and iCC