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[PMC free article: PMC3758473] [PubMed: 18802415] 16

At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)

Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilage

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designed an OoC device consisting of microfluidic channels with a flexible membrane, coated with ECM, where human intestinal cells (Caco-2) were seeded ( Figures 3D-F ) (123)