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EXPERIMENTAL MODEL AND SUBJECT DETAILS Generation of Experimental Animals All animal experiments were performed following IACUC approved procedures (Protocols IS00003893R, IS00006358R, IS00007922R, IS00008736R, and IS00010348R)

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Furthermore, due to questionable significance of animal data and ethical opposition to animal testing, effort has been to put into finding alternative testing methods to identify potential skin toxins 17,18,19

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