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Furthermore, the terms alkyl, alkenyl, alkynyl, aryl, alkylene, arylene, heteroalkyl, heteroalkylene, C3-C8 carbocycle, C3-C8 carbocyclo, C3-C8 heterocycle, C3-C8 heterocyclo, polyether refer to optionally substituted groups with one or more of the substituents selected from: -X, -R, -O', -OR, =0, -SR, -S', -NR2, -NR3, =NR, -CX3, - CN, -OCN, -SON, -N=C=O, -NCS, -NO, -NO 2 , =N 2 , -N 3 , -NRC(=O)R, -C(=0)R, - C(=O)NR 2 , -SO3-, -SO3H, -S(=O) 2 R, -OS(=O) 2 OR, -S(=O) 2 NR, -S(=O)R, - OP(=O)(OR) 2 , -P(=O)(OR) 2I -PO3-, -PO 3 H 2 , -C(=O)R, -C(=O)X, -C(=S)R, -CO 2 R, - CO 2 , -C(=S)OR, C(=O)SR, C(=S)SR, C(=O)NR 2 , C(=S)NR 2 , and C(=NR)NR 2 , where each X is independently a halogen: -F, -Cl, -Br, or -I

That could be because of the tangibility of direct mail

Halliwell & Gutteridge, 2015)

If human progress continues on its current trajectory or we can work out how to build a self-improving AI without it deciding to turn us all into paperclips it doesnt seem implausible that we will one day untangle our telomeres and make ageing an inconvenience rather than an inevitability

This stage is common in older men but can appear earlier in those with strong genetic predisposition

doi: 10.1093/ije/30.3.457