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Description

10.1021/pr0606575 24 DirrH.ReinemerP.HuberR

Consult your doctor if you are pregnant or breastfeeding

253 In senescent cells, mitochondrial proton leak was observed, associated with the weakened proton gradient and further reducing the efficiency of ATP synthesis

C.DengY.MaoY.WangC.ZhangT.et al

Author contributions DY: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing original draft

We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]