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Animal and in-vitro studies consistently show BPC-157 accelerates healing of tendon-to-bone interfaces, ligament reconstruction, muscle crush injuries, and intestinal mucosa damage

Introduction Among the hundreds of peptides studied in cosmetics and regenerative medicine, GHK-Cu (glycyl-L-histidyl-L-lysine copper) holds a unique position

Histochemical and immunohistochemical staining Tissue cryosections were fixed for 15 min, incubated with SA--gal staining at 37 C overnight in the dark according to the manufacturers instructions (Solarbio, Beijing, China)

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All histological sections were blindly evaluated by the same investigator

The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology