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J Cell Biol 217(10):36253639 Kuroda Y, Mitsui T, Kunishige M, Shono M, Akaike M, Azuma H, Matsumoto T (2006) Parkin enhances mitochondrial biogenesis in proliferating cells

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Importantly, complete response was associated with improved survival.129 The efficacy of this combined therapy results from the vasoconstriction effect induced by terlipressin on the splanchnic vascular district and the expansion caused by albumin, which together improves effective hypovolemia and ultimately restores renal perfusion.15,94,127,129131 Controversial indications for albumin therapy in cirrhosis The beneficial effect of human albumin was also assessed in patients with cirrhosis and bacterial infections other than SBP.15 In fact, non-SBP infections also associate with an increased risk for renal failure, which occurs in more than one third of the patients.132 However, the risk seems to be particularly significant in sub-diaphragmatic infections.133 Guevara, et at