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C1-27 , SC-144 and As 2 O 3 were administered intraperitoneally in a fixed volume of 100 l, on a 5 days on/2 days off schedule

7 (download XLSX Statistical Source Data

The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)

Inflammation and the potential implication of macrophage-microglia polarization in human ASD: an overview

Moreover, the amount of AGEs in the brain and CSF increases with age, and is more prevalent in people with Alzheimers disease [49, 50] and multiple sclerosis [51]

Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P et al