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It may inhibit reactive oxygen species (ROS) production and improve mitochondrial function, thereby attenuating the chronic low-grade inflammation commonly observed in hemodialysis patients

However it should be noted that according to Stanley [168], over the past 40 years, there have been only two clear examples of disorders directly due carnitine deficiency that have provided evidence of unequivocal benefit from carnitine treatment

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After the first developed PARP inhibitor, olaparib, multiple PARP inhibitors such as niraparib, veliparib, and talazoparib were subsequently developed and tested in different phases of clinical trials

Figure 2 2.5

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