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Causes of Pigmentation The most common causes of pigmentation are: UV Exposure Radiation from the sun increases melanin production as a protective mechanism, which over time leads to sunspots, freckles, and uneven skin tone

& McKinley, G

S.|Spieles-Engemann, A

Here, this present review aims to systematically elaborate on the underlying immunological mechanisms of AILI, its relevance to immune cells and their effector molecules, and briefly discuss great therapeutic potential based on inflammatory mediators