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Studies in animals show that systemic administration produces healing effects at distant sites

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Discontinue use and seek medical advice if you experience severe irritation, blistering, or a widespread rash

Transient erythema, pruritus, or stinging may develop at the application site, typically resolving with continued use or brief treatment interruption

Investigations are guided by clinical suspicion rather than routine panels: for example, thyroid function tests and ferritin may be checked if symptoms suggest deficiency or thyroid disease, while an androgen profile may be appropriate in women presenting with menstrual irregularity, hirsutism, or acne