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Methods All animal procedures were performed in accordance with the guidelines for the Care and Use of Laboratory Animals of the University of Science and Technology of China and approved by the Animal Ethics Committee of the University of Science and Technology of China

1.078% decrease in blemishes & freckles

After 24 h of co-culture, the degree of hybridoma activation was determined on a BD FACSCanto Flow Cytometry System with respect to the percentage of sGFP + hybridoma cells

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Co-targeting of IGF-1R (Dalotuzumab) and EGFR (Erlotinib[80], Cetuximab [50]) however did not improve outcomes