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The objective of this critical review is to initially explore the molecular and cellular mechanisms in the peripheral and central nervous systems associated with TINP, including mitochondrial dysfunction, oxidative stress, axonal degeneration, maladaptive neuroplasticity, and neuroimmune activation

Transfusion 58 , 27972806 (2018)

doi: 10.3390/ijms24021526 205 SaitouM.FuruseM.SasakiH.SchulzkeJ

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The effect of this synergistic treatment is ASS-dependent, and the activity of the enzymes mentioned above can be restored by transfection of ASS, eliminating the sensitivity of tumor cells to ADI-PEG20 combined with 5-FU treatment