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Based on the patient population we see in Doral, the strongest candidates typically include: Patients with chronic or multi-site injuries: TB-500s systemic distribution makes it particularly relevant for patients with injuries across more than one joint or tissue type, where localized injection alone would require multiple sites per session

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In studies conducted under the auspices of the National Toxicology Program, groups of rats were fed diets containing 0, 150, 300 or 600 ppm triamterene, and groups of mice were fed diets containing 0, 100, 200 or 400 ppm triamterene

All safety data derives from animal studies