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Interestingly, this work resonates with the aforementioned in vitro study demonstrating the protective effect of Set7/9 inhibition in cardiomyocytes subjected to hypoxia-reoxygenation achieved through Nrf2 stabilization and activation of antioxidant genes 97

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MDA: Malondialdehyde assay

However, the various functional groups present in peptide sequences and the need to perform chemistry under mild and aqueous conditions make selective protein functionalization one of the greatest synthetic challenges

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