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Research has demonstrated that during AP, changes in membrane permeability of acinar cells and organelles result in mitochondrial DNA (mtDNA) being released and the NLRP3 inflammasome becoming activated, thereby driving inflammation (15)

Faghfouri AH, Seyyed Shoura SM, Fathollahi P, et al

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In cases where OTC medications are not effective or acne has worsened, professional medical treatment is necessary