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The binding of AGEs to their receptor (RAGE) activates the AGEs/RAGE signaling pathway, inducing inflammation, oxidative stress, cell apoptosis, insulin resistance, and damage to pancreatic cells 92

The MDA concentration in cell lysates was assessed by a cell malondialdehyde (MDA) assay kit (Nanjing Jiancheng Bioengineering Institute, A003-4-1)

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Cellular redox balance and oxidative stress mechanism research

Thus, to better understand at which stage GSH is essential in the maintenance of B cells in the adult mouse, we measured Gclc expression and total GSH in TrB from mutant and control mice