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RAMSES 2025: The 13th Annual Robotic Assisted Microsurgical & Endoscopic Society Symposium

This AOP identifies the deposition of ionizing energy as the MIE, leading to DSB and subsequent mutations due to the errors in DNA repair mechanisms

In many cases, it is not simply diet

A number of research confirmed a strong involvement of oxidative stress in the pathophysiology of neurodegenerative diseases through a variety of mechanisms including induction of oxidation of macromolecules such as nucleic acids, proteins, lipids, mitochondrial dysfunction, glial cell activation, amyloid deposition, apoptosis, and proteasome dysfunction [3, 5, 10, 11]

This process is especially important for athletes and physically active individuals, as it supports endurance, reduces fatigue, and may help improve exercise performance

This local hepatic inflammation leads to further recruitment of systemic inflammatory cells, such as neutrophils, T-cells and monocytes, which perpetuate additional inflammation, hepatic fibrosis, hepatocyte cell death (68, 72, 73) that ultimately leads to rapid progression to multiple organ failure (74)