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b) Developing more representative models that incorporate both tumor heterogeneity and microenvironmental interactions, which are critical for recapitulating the full spectrum of resistance mechanisms

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121 However, prolonged AMPK-dependent activation of p53 can ultimately drive cells into senescence 121 (Fig

The impaired gut barrier function is a characteristic of I/R injury and has broad systemic effects, including the development of endotoxemia (Sharapov et al., 2017

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848-854, 1997 Victor M, Ropper AH

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