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Consistent with this observation, inhibition of PKC enhances the suppressive capacity of Tregs, restores the impaired function of Tregs from rheumatoid arthritis patients, and blocks autoimmune responses in mouse models of colitis (143)

Most events were mild to moderate and improved as the dose stabilized

Therapeutic potential of astrocyte purinergic signalling in epilepsy and multiple sclerosis

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The signaling pathways activated through a GPCR are limited by the primary sequence and tertiary structure of the GPCR itself but ultimately determined by the particular conformation stabilized by a particular ligand, as well as the availability of transducer molecules

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