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Description

GCase activity is correlated with increased neuroinflammation, -syn aggregation, and neurodegeneration [159,160,161]

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Under normal conditions, microglia maintain neuronal function through synaptic pruning, but in early AD, hyperactive neurons trigger aberrant microglial phagocytosis, causing synaptic loss and disrupted neural signaling (Zhong L

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Huang Z, Zhang W, An Q, Lang Y, Liu Y, Fan H, et al

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