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Mutations in the ORF3a protein, such as T223I and S171L abrogated induction of LDs and led to deficient replication and lower virus yield in vitro (Wang et al., 2023)

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These findings indicate that these lipids play an important role in the pathogenesis of PD, as they were reported to be higher also in patients without GBA mutations

doi: 10.1016/j.nut.2018.11.015 178 WeberATShahNDSaukJLimketkaiBN