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Moreover, adverse effects such as nasal irritation and epistaxis (nosebleeds) can further discourage patients from adhering to their treatment plans [5]

Thomas MR, Storey RF

Molecules 2016;21(9):1130

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Third, the causal relationship between ferroptosis and stone pathogenesis lacks rigorous validationexisting data only confirm oxalate induces ferroptosis, but it remains unclear whether ferroptosis directly promotes crystal adhesion, tubular injury, or inflammatory responses (key steps in stone formation) or is merely a secondary consequence of oxalate toxicity

Treatment of COVID-19 with NAC (dosage: 600 mg) could provide a prophylactic benefit, and at higher dosage (1200 mg) could serve a therapeutic regimen when administered at the first onset of symptoms 606