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Similar results were observed in another phase 1 clinical trial study that used a different synthetic -syn mimicking epitope called AFFITOPE PD03A (NCT02267434)

The possible mechanism for enhanced pharmacological response of liposomal CoQ10 across blood brain barrier can be phospholipid bilayer of liposome, facilitating the permeation of the drug across the biological membrane and release of entrapped CoQ10 at the target site via passive diffusion [68,69,70]