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Notably, the side chain of W276 6.48 rotates nearly 180 and tilts ~3 toward the extracellular end, and together with the side chain of F279 6.51 , it also displays upward movement, therefore pushing out the extracellular end of TM6 and enlarging the ligand-binding pocket, subsequently impeding the formation of a salt bridge by dragging R283 6.55 away from E124 3.33 (Fig

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Translational Research in Anatomy, 16,100041 Wong T.L., Kikuta S., Iwanaga J., Tubbs R.S