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Different forms of B12 were investigated in conventional C57BL/6J mice housed three per cage ( n = 6) by supplementing cyanocobalamin and methylcobalamin (Thermo Fisher Scientific, MA, USA) at 10 g/ml and 40 g/ml in drinking water

The Ames test showed no mutagenicity, chromosomal aberration assays detected no genotoxicity, and micronucleus testing revealed no clastogenic effects

Encourage patients to plan treatments at least two weeks before significant events to avoid visible bruising

Proton pump inhibitor (PPI) users : Long-term acid suppression decreases protein-bound B12 release

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