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(2) Antiinflammation: inhibition of inflammatory mediators (e.g., NSAIDs) or selective targeting of COX2 via prodrugs is depicted to attenuate inflammationdriven oxidative stress

The study by Shi et al

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Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150

Step 2: Treat Once protection is non-negotiable, layer your active treatments strategically

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