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Proc Natl Acad Sci U S A (2014) 111(17):61318.10.1073/pnas.1318948111 90 ShlyuevaDStampfelGStarkA

Even though eggs were harvested and consumed dating back to the prehistoric era, the chicken was only formally domesticated for consumption and egg production in Southeast Asia and India before 7500 BCE

Nicotinamide treatment robustly protects from inherited mouse glaucoma

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116 More recently, the transcription factor Forkhead box class O1 (FoxO1) was found to be required for exercise-induced physiological cardiac hypertrophy, but was not necessary in mediating PI3K activation-induced physiological hypertrophy in vivo

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