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1,13,14 Metformin, an insulin-sensitizing agent, is a second-line treatment option for metabolic concerns when oral contraceptives and lifestyle changes do not provide satisfactory results

[DOI] [PubMed] [Google Scholar] 165.Lu C, Xu W, Zhang F, Shao J, Zheng S

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The Notch signaling pathway promotes M1 polarization to enhance pro-inflammatory responses, while its inhibition can favor M2 polarization, indicating its versatile influence on macrophage functionality in various disease contexts (252, 253)