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Therefore, it may work by increasing intracellular matrix turnover and replacing old matrix components with new ones [15]

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10.1007/s11596-018-1989-8 214 YuS.LiuF.WangC.ZhangJ.ZhuA.ZouL.et al (2018)

Of note, most indexes were strongly reversed in the caffeine group, although AST activity, fasting blood glucose, and the HOMA-IR index were improved in the ECGC group

PMID: 12 MaidstoneRJTurnerJVetterCDashtiHSSaxenaRScheerFet al

We previously showed that serine-141 and histidine-296 are required for enzymatic activity 16 , and docking predicts that the thiol ring of lipoate is proximal to these residues