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The blood cell fraction was dialyzed with a cellulose tube (Sanko) and loaded onto TSK-GEL DEAE-5PW columns (7.5 75 mm, TOSOH)

Mechanistic studies indicate that ATR-I exerts anti-inflammatory effects by regulating NLRP3 inflammasome-associated signaling pathways: it significantly reduces levels of key pro-inflammatory factors NO and TNF-, while suppressing expression of inflammatory mediators such as MCP-1 and MMP-9 in microglia, thereby exerting its anti-inflammatory neuroprotective effects ( Tripterygium wilfordii extract (10 g/kg, administered for 7 days) effectively prevents the loss of dopaminergic neurons in the substantia nigra and maintains the function of the nigrostriatal pathway, while significantly improving motor deficits in MPTP-induced PD mouse models

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12 The pathology then continues to propagate rostrally to more central structures, such as the substantia nigra, leading to the emergence of motor symptoms

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Nucleic Acids Res 36:71927206 Parnham MJ, Sies H (2013) The early research and development of ebselen